Calcium induces electron transfer in NADPH oxidase 5
نویسندگان
چکیده
منابع مشابه
The participation of the hemes of flavocytochrome b245 in the electron transfer process in NADPH oxidase.
filgrastim-primed bone marrow versus filgrastim-mobilized peripheral blood stem cell transplantation in lymphoma patients. Blood 92:3489, 1998 7. Mandelam RK, Vento CA, Stiff PJ, Brott DA, Smith AK: Stem and progenitor cell content and ex vivo expansion potential of human bone marrow primed in vivo with G-CSF. Blood 90:344b, 1997 (abstr, suppl 1, part 2) 8. Martinez C, Urbano-Ispizua A, Rozman ...
متن کاملAldosterone Induces Oxidative Stress Via NADPH Oxidase and Downregulates the Endothelial NO Synthesase in Human Endothelial Cells
Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. Recent studies suggest that Aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. However, its exact cellular mechanisms remain obscure. This study was undertaken to examine the effect of Aldo on superoxide production in human umbilical artery endothelial cel...
متن کاملConformational States and Kinetics of the Calcium Binding Domain of NADPH Oxidase 5
Superoxide generated by human NADPH oxidase 5 (NOX5) is of growing importance for various physiological and pathological processes. The activity of NOX5 appears to be regulated by a self-contained Ca(2+) binding domain (CaBD). Recently Bánfi et al. suggest that the conformational change of CaBD upon Ca(2+) binding is essential for domain-domain interaction and superoxide production. The authors...
متن کاملCalcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5.
Excessive synthesis of reactive oxygen species contributes to the pathology of many human diseases and originates from changes in the expression and posttranslational regulation of the transmembrane NADPH oxidases (Noxes). Nox5 is a novel Nox isoform whose activity is regulated by intracellular calcium levels. We have reported that the activity and calcium-sensitivity of Nox5 can also be modula...
متن کاملDiabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction.
Recent data suggest that diabetes is a risk factor for pulmonary hypertension. The aim of the present study was to analyze whether diabetes induces endothelial dysfunction in pulmonary arteries and the mechanisms involved. Male Sprague-Dawley rats were randomly divided into a control (saline) and a diabetic group (70 mg/kg(-1) streptozotocin). After 6 wk, intrapulmonary arteries were mounted fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.611.13